Soluble Polymer Complexes of Ceftriaxone and Cefotaxime with Cellulose Sulfate Acetate Salt Forms and Their Adsorption on Carbon Sorbents

Abstract

Effect of the nature of a counterion in the salt forms of cellulose sulfate acetate on the composition, hydrodynamic characteristics, surface activity, and sizes of supramolecular structures of water-soluble complexes with ceftriaxone and cefotaxime is studied. The relationship between the position of counterion in the lyotropic series of alkali-metal cations and the properties of complexes is ascertained. It is shown that the amount of the bound antibiotic decreases in the sequence K+–Na+–Li+. The sizes of micellar-like supramolecular structures in solution and in the solid phase (films cast from solution) change in a similar manner. These structures can form because of hydrophobization of the macromolecular chain of polyelectrolyte. It is found that the adsorption of ceftriaxone and cefotaxime polymer complexes on various carbon sorbents depends on the porous structure of the activated carbon and makes it possible to provide the transfer of antibiotic to the small intestine in the unchanged form. This opens the possibility to create a new tablet dosage form of cephalosporin antibiotics while fully preserving their pharmacological activity.