Abstract
Nowadays, it is still difficult for molecularly imprinted polymers (MIPs) to achieve homogeneous recognition since they cannot be easily dissolved in organic or aqueous phase. To address this issue, soluble molecularly imprinted nanorods have been synthesized by using soluble polyaniline doped with a functionalized organic protonic acid as the polymer matrix. By employing 1-naphthoic acid as a model, the proposed imprinted nanorods exhibit an excellent solubility and good homogeneous recognition ability. The imprinting factor for the soluble imprinted nanoroads is 6.8. The equilibrium dissociation constant and the apparent maximum number of the proposed imprinted nanorods are 248.5 μM and 22.1 μmol/g, respectively. We believe that such imprinted nanorods may provide an appealing substitute for natural receptors in homogeneous recognition related fields.
Highlights
In nature, antibodies and enzymes play vital roles in various biological processes such as molecular recognition, signal transduction, and immune response (Baker, 2015; Schwalm et al, 2016)
The soluble molecularly imprinted nanorods (MINs) was synthesized by chemical oxidation polymerization in aqueous solution in the presence of template 1-naphthoic acid (1-NA), monomer aniline, functionalized protonic acid dodecylbenzene sulfonic acid (DBSA), and the initiator ammonium persulfate
We have reported for the first time a general and facile approach for the synthesis of a fully soluble molecularly imprinted polymers (MIPs) in organic solvent with an excellent homogeneous binding capability and selectivity toward the template
Summary
Antibodies and enzymes play vital roles in various biological processes such as molecular recognition, signal transduction, and immune response (Baker, 2015; Schwalm et al, 2016). It should be noted that almost all of the recognition processes of natural receptors take place in homogeneous systems Until now it is still a big challenge for MIPs to achieve homogeneous molecular recognition since they are highly cross-linked polymers and cannot be dissolved in organic or aqueous phase. This issue seriously limits the wide applications of MIPs in various areas such as homogeneous catalysis (Liu and Wang, 2010), chemical sensing (Liang et al, 2010, 2017), and medical treatment (Cutivet et al, 2009)
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