Abstract
The Ebstein-Barr virus-transformed human lymphoblastoid cell line PGLC-33H releases a migration inhibitory factor (MIF) of MW ~ 20,000 daltons. This MIF may appear free in serum-free culture supernatants or may be associated with a carrier material as a complex of MW ~ 60,000 daltons, from which the MIF can be dissociated. The free form of MIF possesses, or is associated with a suppressor activity for pokeweed mitogen-induced immunoglobulin synthesis. This suppressor activity is heat (56 °C) and acid pH stable but 2-mercaptoethanol sensitive and cannot be attributed to α-interferon or lymphotoxin.
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