Abstract
Serum soluble interleukin-2 receptor levels, basal thyrotropin, total thyroxine, total triiodothyronine and free triodothyronine were assayed in 29--otherwise healthy--patients with pulmonary tuberculosis before initiation of anti-tuberculosis treatment and after two weeks of therapy. Twenty seven out of 29 patients presented low-normal total triiodothyronine levels, showing a statistical elevation after anti-tuberculosis therapy. Total triiodothyronine levels before anti-tuberculosis therapy were inversely correlated with levels of serum soluble interleukin-2 receptors. Further investigation on the relationship between soluble interleukin-2 receptor's levels and thyroid hormones in non-thyroidal disease can be envisaged.
Highlights
Antigen stimulation of resting T-cells triggers synthesis and secretion of interleukin-2, as well as the membrane expression of interleukin-2 receptors [1]
Normal peripheral blood mononuclear cells and certain lines of T- and B-cell origin release, after its membrane expression, a soluble form of interleukin-2 receptor; this appears to be a consequence of cellular activation of various cell types that may play a role in the regulation of the immune response [1,2]
Recent studies have shown that patients with tuberculosis (TB) present with low to normal free and total triiodothyronine levels, which rapidly elevate after anti-TB treatment [6,7,8]
Summary
Antigen stimulation of resting T-cells triggers synthesis and secretion of interleukin-2, as well as the membrane expression of interleukin-2 receptors [1]. Normal peripheral blood mononuclear cells and certain lines of T- and B-cell origin release, after its membrane expression, a soluble form of interleukin-2 receptor (sIL-2R); this appears to be a consequence of cellular activation of various cell types that may play a role in the regulation of the immune response [1,2]. Recent studies have shown that patients with tuberculosis (TB) present with low to normal free and total triiodothyronine levels, which rapidly elevate after anti-TB treatment [6,7,8]. The aim of the present study was to evaluate thyroid function parameters and/versus sIL-2R-α (one of the receptor’s subunits) in patients with pulmonary TB before and after initiation of anti-TB therapy
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