Abstract

When human citrated plasma is dialysed against a phosphate buffer containing Ca ++. citrate anions are removed, thrombin is generated and soluble fibrinogen derivatives (fibrin monomers and/or soluble fibrin polymers) are formed. These derivatives are able to combine with human or bovine elastin to form a very stable addition product or adduct. The formation of the adduct is dependent on time, Ca ++ and thrombin concentrations.

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