Soluble fibrin (ethanol gelation test) and fibrin(ogen) degradation products in suspected thrombosis with reference to the 125I‐fibrinogen uptake test for detection of thrombus formation

Abstract

When symptoms of deep vein thrombosis is confirmed by venography (established DVT), the 125I‐fibrinogen uptake test (FUT) will discriminate between thrombi which incorporate the isotope (FUT+) and those who do not (FUT−). These are probably forming and non‐forming thrombi, respectively. The aim of the present study was to compare the occurrence of fibrinaemia, using the ethanol gelation test (EGT), in patients with FUT+ and FUT− thrombi. Fibrin(ogen) degradation products (FDP) were also analysed.The study included 64 medical patients with suspected DVT, confirmed by venography in 43 and precluded in 21 patients. Isotope studies included 12 patients with FUT+ and 13 with FUT− thrombi.Significant concordance between hemostatic parameters and venography was found only for FDP. The sensitivity of FDP on admission was 53%, but also patients without DVT had increased values (5%, P < 0,001).Among patients with documented DVT, a positive EGT was specific for those with FUT+ thrombi which incorporated the isotope in at least 4 recording positions, whereas the sensitivity on admission was 89% (P < 0,005). A positive EGT was not associated with other variables, including disorders other than DVT. The strong association between abnormal isotope findings and a positive EGT suggests that FUT+ thrombi may induce fibrinaemia.