Abstract
Introduction: Previous studies have suggested the use of soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. The aim of this study was to assess the sCD26 concentration in a large cohort to evaluate its association to epidemiologic parameters and CRC-related symptoms/pathologies.Subjects and methods: Serum samples were collected from 2,754 putatively healthy individuals with ages ranging from 30–65 years, and with personal or familial history of polyps, CRC and/or CR symptoms. sCD26 levels were measured by ELISA.Results: No association was found between the sCD26 concentration and age (< 50 and ≥ 50), the personal or familial history of polyps or CRC, rectal bleeding, haemorrhoids or diverticula. However, sCD26 was related to non-inflammatory benign pathologies (excluding rectal bleeding, changes in bowel habits, haemorrhoids, diverticula) and to inflammatory benign pathologies.Discussion: Our results confirm that the sCD26 can be easily offered and evaluated in a large cohort. Additionally, the validation of sCD26 as a tumour marker for screening and case-finding purposes requires a further comparison with an established non-invasive test like the faecal occult blood.
Highlights
Previous studies have suggested the use of soluble CD26 as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas
Only 2% (55 individuals) of the cohort were women compared to the 2,699 men, no statistically significant differences were detected in the soluble CD26 (sCD26) levels (p = 0.190)
In previous works we observed that the soluble CD26 levels were diminished in CRC patients as compared to healthy donors [2,7] suggesting its utility in the early diagnosis of CRC and advanced adenomas
Summary
Previous studies have suggested the use of soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. Results: No association was found between the sCD26 concentration and age (< 50 and 50), the personal or familial history of polyps or CRC, rectal bleeding, haemorrhoids or diverticula. The DPP-IV activity cleaves two N -terminal amino acids from polypeptidic chains with proline or alanine in the second position, which otherwise are resistant to most proteases [4]. It participates in the process of dietary protein assimilation and in the cleavage or clipping of many regulatory peptides such as several chemokines, integrins or neuropeptides [3,4]. De Chiara et al / Soluble CD26 levels and its association to epidemiologic parameters in a sample population
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