Abstract
Abstract In Yoshida hepatoma cells, adenylate cyclase was found to be present in the plasma membrane as well as in the supernatant fraction. Both activities were lower than that obtained with liver membranes. During tumor growth enzyme activity decreased in the membrane and rose in the supernatant. The response of soluble and membrane-bound adenylate cyclase to epinephrine, glucagon and fluoride was markedly different. The hormone concentrations required for maximal effect were higher for the tumor than for the liver enzyme. These findings suggest that tumor cells tend to escape hormonal control.
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