Solubilty Enhancement of Naproxen Sodium Using Different Carriers by Solid Dispersion

Abstract

In the existing study an attempt has been made to increase the in vitro dissolution rate of poorly water-soluble drug naproxen, by utilizing novel solid dispersion methods are one of the most auspicious methods to enhance the oral bioavailability of poorly water soluble drug. naproxen sodium formulations were planned out by using melting method or fusion method, and using carrier like PVP-K30 and PEG4000. the formulation were planned out with the above-mentioned carriers in three different drug-carrier (w/w) ratios of 1:1, 1:2 and 1:3. the prepared solid dispersion was subjected for percentage practical yield, drug content, and FTIR studies. absence of significant drug-carrier interaction was confirmed by FTIR data. in-vitro release profiles of all solid dispersions (SD1 to SD6) were analogously evaluated and also studied against pure naproxen sodium. solid dispersion of formulation (SD6) naproxen sodium and PVP-K30 combination planned out in (1:3) ratio showed excellent solubility and the dissolution rate was found to be 98.97% drug release at 24 min was chosen as the absolute best formulation in this study. solubility of naproxen sodium was increased as the concentration of carriers increased.