Abstract
Phospholipid liposomes were prepared using deep sea water and the liposomes obtained were used to solubilize oil-soluble medicines. In addition, the dispersion stability of the liposomes was examined. Deep sea water treated with reverse osmosis membrane (RO water) gave liposomes, whereas 100% deep sea water failed to yield liposmes. Soybean lecithin liposomes solubilizing oil-soluble medicine dispersed in RO water was more stable than those dispersed in distilled water. The time needed for the liposome-medicine system to attain solubilization equilibrium was shorter in RO water than in distilled water. Moreover, a better stability was suggested for easily oxidizable vitamin A when it was solubilized in liposomes dispersed in RO water.
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