Abstract
The aqueous solubility of non-steroidal anti-inflammatory drugs (NSAIDs) Ketoprofen, Ibuprofen, Diflunisal and Naproxen were measured in the presence of the Tween series surfactants at 37°C. Results showed that the solubility of NSAIDs in the Tween solutions was approximately proportional to Tween concentration; the ability of Tween series surfactants to solubilize NSAIDs in the present study was Tween-80 > Tween-60 > Tween-40 > Tween-20; the order of increased solubility of NSAIDs in Tween series surfactants at a constant Tween series and concentration was Ibuprofen > Ketoprofen > Diflunisal > Naproxen. Under suitable conditions Tween series surfactants can be highly effective used to enhance the solubility of NSAIDs.
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