Abstract
Microemulsions based on biocompatible components with high water content are applied to increase the solubility of medicinal drugs of the heterocyclic series indomethacin and 1-[5-(4-chlorophenyl)-3-phenylpyrrole-2-yl]benzimidazole-2(3H)-one (PBI). The solubilizing capacity is characterized quantitatively via spectrophotometry. It is shown that four-component microemulsion water/oleic acid/Tween 80/ethanol increases the limits of indomethacin solubility by more than two orders of magnitude, and that of PBI by more than three orders relative to water.
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