Abstract
Solubilization of cholesterol by mixed micelles of sodium chenodeoxycholate with sodium ursodeoxycholate was investigated in carbonate-tetraborate buffer (Kolthoff) solution at pH 10 and 37°C. It was found that the mixing of the two bile salts gives a negatively synergetic effect on solubilization of cholesterol. The solubilizing power of bile salts for cholesterol was remarkably influenced with the change in mole fraction of sodium ursodeoxycholate (XUDC).
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