Abstract
The interaction of cinnamic acid (CA) and its analogues viz. p-coumaric acid (PCA) and caffeic acid (CFA) with core-shell micelles of a moderately hydrophobic Pluronic® P123 has been investigated using cloud point (CP), viscosity, dynamic light scattering (DLS), small-angle neutron scattering (SANS) and steady-state fluorescence measurements. These solubilizates alter micellar behaviour of copolymer solution dependant on their hydrophobicity. P123 micelles exhibit time-dependent restructuring and responsive growth processes at different rates, depending on pH and in the presence of additives. Thus, restructuring and growth of P123 micelles can be easily tuned up to a substantial extent just by changing the concentration of the additives and the pH of the solution. Considering the medical applications of cinnamic acid and its analogues and considering use of Pluronics® in drug delivery systems, the present study can provide important insight of the possible time-dependant delivery mechanism of drugs.
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