Abstract
Organic compounds with varying structure and functional groups are mixed with water and with each other in order for students to formulate a theory about the molecular basis of solubility. The exercise is designed as a guided-inquiry lab for an introductory biochemistry course for non-science majors. Observations on the effects of polarity, hydrogen bonding, chain length, cyclic versus acyclic, or other structural features on solubility are related to the intermolecular forces discussed in the biochemistry curriculum.
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