Abstract
The solubility of caffeine, theophylline, and theobromine were determined in dioxane-water mixtures, and the solubility curves that were determined showed a multiplicity of peak solubility values. These peak solubility values occurred at about the same solvent composition for the subject compounds studied. A property common to these solvent compositions having the same value is the dielectric constant. These peaks are descriptively referred to as dielectric requirements irrespective of the mechanism operative in causing the formation of these unusual solubility curves. These solubility curves are referred to as solubility profiles. The solubility of caffeine, theophylline, and theobromine were determined in dioxane-water mixtures, and the solubility curves that were determined showed a multiplicity of peak solubility values. These peak solubility values occurred at about the same solvent composition for the subject compounds studied. A property common to these solvent compositions having the same value is the dielectric constant. These peaks are descriptively referred to as dielectric requirements irrespective of the mechanism operative in causing the formation of these unusual solubility curves. These solubility curves are referred to as solubility profiles.
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