Abstract
This investigation was primarily concerned with the application of Hildebrand's solubility equation to the determination of the solubility parameter of selected sulfonamides. The vapor pressure of several selected solvent systems was determined by an isoteniscopic method. These data were used to calculate the solubility parameter of the mixed solvents. The heat of fusion of each sulfonamide was determined by differential thermal analysis. The solubility of the sulfonamides was measured in a series of solvent blends varying in polarity, and the solubility parameter of the sulfonamides was determined from their solubility data. An attempt was made to correlate the solubility parameter with the dielectric constant. The results were found to be linear with respect to the solvent blends of alcohol-water, alcohol-water-propylene glycol, water-glycerin, and dimethylacetamide-water-glycerin. Hildebrand's solubility concept appears to be a useful tool for predicting drug solubility where the solubility parameters of drug and solvent system are close to each other.
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