Solubility of sodium diclofenac in binary water + alcohol solvent mixtures at 25°C

Abstract

Solubility of sodium diclofenac in aqueous binary mixtures of methanol, ethanol and 2-propanol was determined at 25°C. The maximum solubility of the drug was observed at volume fractions of 0.85, 0.90 and 0.50 for methanol, ethanol and 2-propanol mixtures, respectively. The produced data was fitted to the Jouyban-Acree model and its constants were computed, then the back-calculated solubilities were compared with the corresponding experimental values by calculating the mean percentage deviation (MPD) and the overall MPD for three cosolvent systems was 12.6%. The solubility data in water + ethanol mixtures was predicted using a previously trained version of the Jouyban-Acree model and the prediction MPD was 32.0%. The model successfully predicted the solvent composition providing the maximum solubility of the drug, which is an important data in the formulation studies, especially in the early stages of drug discovery investigations.