Abstract
Preferential solvation of N-(9-fluorenylmethoxycarbonyloxy)-succinimide (Fmoc-OSu) in mixtures of DMF (1) + water (2), ethanol (1) + water (2), ethylene glycol (EG, 1) + water (2) and DMSO (1) + water (2) was investigated by inverse Kirkwood–Buff integrals method. In ethanol-rich and intermediate contents, ethanol preferentially solvated Fmoc-OSu; and for the four aqueous co-solvent blends in water-rich composition regions, Fmoc-OSu was preferentially solvated by water. The solvent effect was described through modeling the Gibbs energy change of Fmoc-OSu solubility by linear solvation energy relationships. The main contribution to solubility variation of Fmoc-OSu was the solvent dipolarity-polarizability and solubility parameter. The dissolution and transfer enthalpy, entropy and Gibbs free energy were discussed in detail. Analysis outcomes of thermodynamic dissolution and enthalpy–entropy compensation demonstrated that two different mechanisms, enthalpy-driven and entropy-driven controlled the solubility variation of Fmoc-OSu in the DMF/EG/DMSO + water mixtures; and enthalpy-driven, in the ethanol + water mixture.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
