Abstract
In the present study, the solubility of ketoconazole is measured by a shake – flask method in the binary solvent mixtures of 2-propanol + water at different temperatures. The experimental solubility data are correlated/back-calculated by some cosolvency models i.e. van't Hoff, Yalkowsky, Jouyban-Acree, Jouyban-Acree-van't Hoff, the mixture response surface and the modified Wilson models. Moreover, the density of ketoconazole saturated solutions is fitted by Jouyban-Acree model and the obtained equation is reported. The accuracy of these models is investigated by calculation of the corresponding MRD%. The apparent thermodynamic parameters including dissolution standard enthalpy change (ΔH∘), standard entropy change (ΔS∘), Gibbs free energy change (ΔG∘) for ketoconazole dissolution are calculated by using van't Hoff and Gibbs equations. Moreover, the preferential solvation analysis demonstrates that ketoconazole is preferentially solvated by water in water-rich and in 2-propanol-rich mixtures, but preferentially solvated by 2-propanol in mixtures of composition 0.19 < x1 < 0.58.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
