Abstract
Equilibrium data of the solubility of carbon dioxide in Precirol ® ATO5, Compritol ® 888 ATO and Gelucire ® 43-01, three solid lipid carriers suitable for controlled/sustained delivery, were measured by a static analytical method for three different temperatures each, in a pressure range from 10 to 20 MPa. The influence of the presence of carbon dioxide in the melting point of the lipid matrices was also studied by a visual method for pressures up to 30 MPa. All the compounds studied presented a similar behaviour in the presence of carbon dioxide, showing a decrease in the melting points between 5 and 13 °C, whereas the solubility of carbon dioxide varies from 0.3 to 0.5 g/g of lipid compound. These results are of utmost importance to design supercritical fluid processes for particle formation at lower operating costs.
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