Abstract
The solubilities of the isomers of benzene hexachloride in rat fat mechanically removed from adipose tissue were determined at 37° and found to be: alpha, 4.05%; beta, 0.66%; gamma, 12.55%; and delta, 19.10%. A parallelism between the solubility of the isomers in rat fat and their solubility in benzene, decahydronaphthalene, toluene, and acetic acid shows that rat fat behaves as a simple solvent in vitro. The equilibrium storage levels of the BHC isomers following dietary intake are unrelated to the solubility of the isomers in rat fat, with the exception that solubility is a limiting factor. The reported differences in storage must be explained by differences in the metabolism of the isomers and not by differences in their solubility.
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