Solubility of Acetanilide and Several Derivatives in Sucrose Solutions

Abstract

The solubilities of acetanilide, acetoacetanilide, and the p-methyl, p-ethoxy, p-hydroxy, and p-amino derivatives of acetanilide were determined in aqueous sucrose solutions. The solubilities of all solutes were found to change significantly with changes in the concentration of sucrose solutions. The solubility curves indicate the changes probably involve solvent polarity, as indicated by dielectric constant of the solvent, and decrease in the activity of water. The solubility changes obtained for acetanilide and the several para derivatives were found to show a fair correlation with respect to the magnitude of solubility in water. This indicates a possibility of predicting solubility changes for the remainder of the compounds if the solubility change for one of the compounds is known. The solubilities of acetanilide, acetoacetanilide, and the p-methyl, p-ethoxy, p-hydroxy, and p-amino derivatives of acetanilide were determined in aqueous sucrose solutions. The solubilities of all solutes were found to change significantly with changes in the concentration of sucrose solutions. The solubility curves indicate the changes probably involve solvent polarity, as indicated by dielectric constant of the solvent, and decrease in the activity of water. The solubility changes obtained for acetanilide and the several para derivatives were found to show a fair correlation with respect to the magnitude of solubility in water. This indicates a possibility of predicting solubility changes for the remainder of the compounds if the solubility change for one of the compounds is known.