Abstract
Abstract The solubility of 1-adamantanamine hydrochloride (1-AH) in ethanol, acetic acid, distilled water, N -methylpyrrolidone (NMP), N,N -dimethylformamide (DMF) and dimethylacetamide (DMAC) between 283.15 K and 333.15 K was measured using a laser monitoring observation technique. Results of these measurements were correlated with the NRTL equation and a semi-empirical equation. For six solvents studied, the data are well fitted with the two equations, which can be used as a useful model in the production process of 1-AH.
Highlights
The solubility of 1-adamantanamine hydrochloride (1-AH) in ethanol, acetic acid, distilled water, N-methylpyrrolidone (NMP), N,N-dimethylformamide (DMF) and dimethylacetamide (DMAC) between 283.15 K and 333.15 K was measured using a laser monitoring observation technique
1-Adamantanamine hydrochloride (Schild and Sutton, 1965; Oxford and Schild, 1965), is a synthetic organic compound clinically used as an antiparkinsonism agent, as well as an antiviral drug (Davies et al, 1964; Van Voris et al, 1981; Bryson, 1982; Paci et al, 2001)
Crystal habit plays an important role in affecting the crystal product physicochemical properties, such as solubility, dissolution rate, compressibility, and bulk density, that have an effect on the product biological activity and production cost
Summary
The solubility of 1-adamantanamine hydrochloride (1-AH) in ethanol, acetic acid, distilled water, N-methylpyrrolidone (NMP), N,N-dimethylformamide (DMF) and dimethylacetamide (DMAC) between 283.15 K and 333.15 K was measured using a laser monitoring observation technique. The dynamic method is used as a common approach in solubility measurement (Liu et al, 2011), which incorporates laser techniques to monitor the dissolution process of the solid solute. Given the overwhelming advantages of the dynamic method (Jouyban-Guaramaleki et al, 2014; Qiao et al, 2014), it is used in this research to measure the solubility of 1-AH in six pure organic solvents, including ethanol, acetic acid, distilled water, NMP, DMF and DMAC between 283.15 K and 333.15 K at atmospheric pressure.
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