Abstract
Solid solubility is a significant physical property for a drug development and design. In the present work, the domperidone solubility, which has less study in the near-term, was reported, which was determined by the shake-flask method in twelve green solvents e.g. methanol, ethanol, isopropanol, n-propanol, n-butanol, isobutanol, acetonitrile, N,N-dimethylformamide (DMF), water, dimethyl sulfoxide (DMSO), N,N-dimethylacetamide (DMA), ethylene glycol (EG) at the temperatures from 278.15 to 318.15K under atmospheric pressure (p=101.2kPa). The domperidone solubility in the twelve solvents increased with the increasing temperature. At a desired temperature, they obeyed the following order from high to low in these solvents: DMA>DMSO>DMF>butanol>n-propanol>(isobutanol, EG)>ethanol>isopropanol>methanol>acetonitrile>water. The experimental solubility was described mathematically with the Buchowski–Książczak λh equation, Apelblat equation Wilson model and NRTL model. The largest percentage of relative average deviation was 3.28×10−2, and the maximum value of root-mean-square deviation was 3.16×10−5. On the basis of the Wilson model, the mixing properties, e.g. mixing Gibbs energy, mixing enthalpy, mixing entropy, activity coefficient at infinitesimal concentration and reduced excess enthalpy were computed. Moreover, the solvent effect was studied by using the concept of Kamlet-Taft Linear Solvation Energy Relationship. The type and extent and direction of solvent-solvent and solute-solvent interactions were identified.
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