Solubility Measurement of Cholesterol in Several Solvents from 283.2 to 323.2 K

Abstract

The solubilities of cholesterol in methanol, anisole, acetic acid, ethyl acetate, heptane, methyl isobutyl ketone (MIBK), and mixed solvent (ethanol–MIBK) are determined in the temperature range of 283.2 to 318.2 K. The experimental solubilities of cholesterol in pure solvents and binary mixed solvents are found to increase with increasing temperature. In the binary mixed solvent (ethanol–MIBK), the cholesterol solubilities with increasing mass fraction of ethanol first increase and then decrease. The maximum cholesterol solubility can be obtained when the mass fraction of ethanol is approximately 10%. The solubilities of cholesterol in MIBK, ethyl acetate, and anisole are larger than those in methanol, heptane, and acetic acid. The experimental solubilities are correlated with the van′t Hoff, modified Apelblat, Yaws, van’t Hoff–Jouyban–Acree, and modified UNIQUAC models. The modified UNIQUAC model shows a better fitting result. The modified UNIQUAC model shows an average relative error (ARD) of less than 9%. The ARD values for the other models are all less than 12%.