Abstract
The solubility of para-methoxyphenylacetic acid in different solvents is of critical significance for the design and optimization of its purification process via crystallization. The present study illustrates new solid–liquid phase equilibrium data of para-methoxy phenyl acetic acid in water, acetonitrile, propan-2-ol, morpholine, toluene, anisole, and binary (propan-2-ol + water, propan-2-ol + toluene) mixed solvents using a static analytical method from 283.15 to 323.15 K at atmospheric pressure. The highest solubility of para-methoxyphenylacetic acid was observed in propan-2-ol and lowest in water, with the maximum solubility effect for propan-2-ol + toluene binary system obtained at 0.5001 solute-free mole fraction of propan-2-ol. The modified Apelblat equation, λh (Buchowski) equation, and nonrandom two-liquid (NRTL) activity coefficient model were used to correlate the experimental solubility data in pure solvents, whereas the binary solvent systems were modeled using the van’t Hoff–Jouyban–Acree, A...
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