Abstract
The basis of purification and further theoretical studies of 2-amino-4,6-dichoropyrimidine is the solubility and solution thermodynamics in different solvents. In this paper, the solubility of 2-amino-4,6-dichoropyrimidine in 10 neat solvents (methanol, ethanol, n-propanol, isopropanol, acetone, acetonitrile, ethyl acetate, 1,4-dioxane, toluene, and cyclohexane) and binary liquid mixtures (ethyl acetate + ethanol) was measured by the isothermal saturation method at temperatures range from 278.15 to 318.15 K, at p = 101.2 kPa. High-performance liquid chromatography (HPLC) was used to analyze the solubility of 2-amino-4,6-dichoropyrimidine in selected solvents. To sum up, the equilibrium mole fraction solubility was highest in 1,4-dioxane (2.619 × 10–2 at 318.15 K) and lowest in cyclohexane (0.02238 × 10–2 at 318.15 K), and ranked as 1,4-dioxane (2.619 × 10–2 at 318.15 K) > acetone (1.630 × 10–2 at 318.15 K) > ethyl acetate (1.471 × 10–2 at 318.15 K) > acetonitrile (0.5048 × 10–2 at 318.15 K) > methanol (0....
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