SOLUBILITY ENHANCEMENT OF MICONAZOLE NITRATE FOR FORMULATION AND EVALUATION OF MUCOADHESIVE GEL

Abstract

The goal of the present investigation is formulation and evaluation of a mucoadhesive gel for buccal delivery after solubility enhancement of very slightly water-soluble drug Miconazole Nitrate. Miconazole Nitrate is imidazole derivative useful in treatment of oropharyngeal Candidiasis, the most common infection in AIDS patients. The method namely solvent deposition with inclusion complex, solid dispersion with inclusion complex and solvent deposition with solid dispersion are used for solubility enhancement. Various polymers such as Lactose, β-CD and PEG-6000 are those polymers which were used for individual methods like SolD, IC and SD respectively all the batches are evaluated for their water solubility and In-vitro release. Enhancement of dissolution rates with increasing quantity of β-CD, Lactose and PEG in the complexes is observed. Water solubility of Miconazole Nitrate is enhanced up to 321.9 times by using combination of methods (solvent deposition with inclusion complex) and mucoadhesive antifungal gel of Miconazole Nitrate is prepared with improved drug release in to the buccal cavity which ensures effective treatment of local fungal infection-Oropharyngeal Candidiasis.  Keywords:Mucoadhesive, dissolution rate, solubility enhancement.