Solubility Determination of Hydroquinone in Dichloromethane, Trichloromethane and Carbon Tetrachloride by Using the Co-solvent Calibration Method

László Kiss,Sándor Kunsági-Máté

doi:10.1007/s10953-019-00922-x

László Kiss, Sándor Kunsági-Máté

Open Access

https://doi.org/10.1007/s10953-019-00922-x

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Abstract

In this report, the solubility of hydroquinone (1,4-dihydroxybenzene) was determined in dichloromethane, trichloromethane and carbon tetrachloride at 298 K by using cyclic voltammetry. By the proposed cosolvent calibration method a mixed solvent was used for the determination of solubility where acetonitrile was the co-solvent. The molar ratios of the two solvents were uniform during the whole procedure both in the calibration solutions and in solutions used for solubility determinations. The solubility of hydroquinone decreased by the decrease of solvent permittivity, which were in dichloromethane 5.683 mmol·L−1, in trichloromethane 2.785 mmol·L−1 and in carbon tetrachloride 0.321 mmol·L−1.

Highlights

The knowledge of the solubility of materials in different solvents and solvent mixtures has great significance for many applications [1,2,3,4,5]
In order to determine the solubility of hydroquinone in the three selected chlorinated hydrocarbon solvents the proposed co-solvent calibration method was tested
Acetonitrile was chosen as the co-solvent as it is miscible with all chlorinated hydrocarbon solvents

Summary

Introduction

The knowledge of the solubility of materials in different solvents and solvent mixtures has great significance for many applications [1,2,3,4,5]. In medical science dimethyl sulfoxide is a solvent which was added to the aqueous solution in low quantity facilitating the dissolution of a large number of compounds [7]. This procedure is complicated as it needs correction equations to calculate the solubility in the aqueous phase containing no dimethyl sulfoxide. There is a solubility determination method that uses a co-solvent introduced into the studied solution [23] but needs a complicated evaluation procedure. The disadvantage of some methods is the need for a large quantity of solvents and solute, and on the other hand they are sometimes time consuming. A reliable new method (co-solvent calibration method) is described which is based on ensuring the uniformity of the factors discussed above during the whole procedure

Experimental

Results and Discussion

Conclusion