Abstract
In this paper, several common solvents including butyl acetate, methyl acetate, ethyl acetate, acetonitrile, 1-butanol, isobutanol, isopropanol, ethanol, 1-propanol, methanol, acetone, and water, were selected as solubility solvents for benzamide. The solubility of benzamide in all solvents increases with the increase of temperature from 283.15 K to 323.15 K, and generally depends on solvents in the following order: methanol > acetone > ethanol > 1-propanol > 1-butanol > isopropanol > isobutanol > methyl acetate > ethyl acetate > butyl acetate > acetonitrile > water. Solubility data in all solvents were well correlated with the temperature by using the NRTL, Wilson and modified Apelblat models. Furthermore, the dissolution thermodynamic properties, which include dissolution Gibbs energy, dissolution entropy and dissolution enthalpy, were also calculated. Based on the above results, ethanol was chosen as the solvent for preparing benzamide cocrystal with benzoic acid. The ternary phase diagram of benzamide-benzoic acid cocrystals in ethanol was constructed, and one stable cocrystal with a stoichiometry of 1:1 was determined and characterized.
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