Solubility and thermodynamics of celecoxib in N-methyl-2-pyrrolidone and (ethanol, 1-propanol) binary solvent mixtures at (293.15 to 313.15) K

Abstract

ABSTRACT This study presents solubility determination and the thermodynamic analysis of celecoxib (CXB) in two kinds of solvent mixtures of N-methyl-2-pyrrolidone (NMP) + ethanol and NMP + 1-propanol at various temperatures (293.15–313.15 K). The density of CXB-free mixtures of NMP + 1-propanol at various temperatures was also measured since the data was not available from the literature. In both systems, the solubility raised with temperature and increased with increasing the amount of NMP in the blends. Measured solubility data were fitted using four mathematical cosolvency models. The resulting MRD% values for all examined models were less than 6.0. The measured densities of the CXB saturated solutions were calculated using an adopted version of Jouyban-Acree model. Further, predictive versions of the model which were trained using the density of drug-free mixed solvents were also used to predict the density of CXB saturated solutions with an overall MRD% of 1.3.