Abstract
In this work, the solubility of the γ - polymorphic form of 5-nitrofurazone (5-nitro-2-furaldehyde semi-carbazone) in mono-solvent systems and binary solvent mixtures was measured from 278.15 to 313.15 K, using a UV spectroscopic method. The results revealed that the solubility increased with increasing temperature in all investigated solvents within this temperature range. The experimental solubility data in the single solvent systems was well represented with the modified Apelblat equation and the NRTL model, while the λh equation and the NRTL model were used to correlate the experimental solubility data in the case of the binary solvent mixtures. In all cases, these models were shown to have an average relative deviation of lower than 5%. In addition, the thermodynamic mixing and dissolution properties of the γ - form of 5-nitrofurazone, in all investigated mono-solvent systems and binary solvent mixtures, were calculated based on NRTL model and experimental solubility data.
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