Abstract
Some novel pyrazolo chalcone derivatives have been synthesized and characterization of these synthesized compounds was done by IR, 1H NMR, 13C NMR and mass analysis. The solubility of pyrazolo chalcone derivatives in methanol, ethanol, 1-propanol, 1-butanol, 1-pentanol, ethyl acetate and acetonitrile was measured by gravimetric method over a temperature range (298.15 to 328.15) K at atmospheric pressure. The solubility of synthesized compounds is found to increase linearly with temperature. Further, in alcoholic solvents, solubility is maximum in 1-pentanol and minimum in methanol whereas in non-alcoholic solvents, solubility is greater in ethyl acetate and minimum in acetonitrile. The experimental solubility data were correlated with temperature by modified Apelblat and Buchowski-Ksiazczak λh equations. The experimental data and model parameters would be useful for optimizing the process of purification. Some thermodynamic parameters such as dissolution enthalpy, Gibb's free energy and entropy of mixing have also been calculated by Van't Hoff analysis. Further, excess enthalpy of solutions has been calculated using Buchowski-Ksiazczak λh equation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
