Abstract
PAMAM dendrimers of full generation (Gn) and half generation (Gn.5) were used as solubility enhancers of riboflavin (B2 vitamin) in methanol. They were found to weakly enhance solubility of B2 (7.2–10.3 times) according to the order: G2≫G2.5>G3≫G3.5>G4. The homogeneous mixtures of Gn (or Gn.5) with B2 of 1:1 molar ratio were obtained by removal of methanol to form oily host-guest complexes. The complexes were released from o/w emulsions and the transdermal permeation of B2 through polyvinyldifluoride (PVDF) and pig ear skin (PES) membranes was estimated. PAMAM dendrimers were demonstrated to promote permeation of B2 according to the order: G2>G3≫G2.5>G3.5>G4 (none). The permeation of fluorescein labeled dendrimers is faster than B2; the diffusion of G2 dendrimer through PES was the slowest of all studied Gn dendrimers, presumably due to absorption inside the skin. On the other hand the G2 was the best permeation enhancer for B2. The water soluble PAMAM dendrimers G2 and G3 can be successfully applied in cosmetic and dermatologic emulsions for this weakly water soluble vitamin.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
