Abstract
The objective of the present work was to improve the solubility and dissolution rate of the poorly water-soluble drug, prochlorperazine maleate (PCM), by preparing nanoparticles using wet media milling method. The first screening design (Plackett–Burman) was applied to screen the significant factors among all the factors. Then, final nanoparticles were optimized by Box–Behnken design and evaluated for independent variables viz. the amount of Pluronic F127, amount of PCM, and milling speed on dependent variables such as particle size, saturated solubility, and dissolution efficiency at 5 min. The Pareto chart revealed a significant effect of three variables among all variables (P < 0.001). Based on the desirability (Box–Behnken), formulation containing 0.5 w/v Pluronic F127, 40 mg of PCM, and 571 RPM speed was considered as an optimized batch. DSC and PXRD studies indicated that dissolution enhancement was due to particle size reduction. It was again confirmed by surface electron microscopy. The study proved a significant improvement in the dissolution rate of prochlorperazine maleate by preparing nanoparticles.
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