Abstract
Available data on the solubility of triamcinolone acetonide in aqueous media are neither complete nor in agreement. Solubility of the steroid in distilled water and in potassium chloride solutions of varying ionic strength was determined at 28, 37, and 50°. Dissolution rates of the steroid in the aqueous media were determined at 28° via a rotating‐disk method. Triamcinolone acetonide solubility in distilled water ranged from 21 mcg. ml.−1 at 28° to 33.6 mcg. ml.−1 at 50°. The differential heat of solution was 4207 cal.mole−1. The intrinsic dissolution rate constant at the maximum agitation intensity employed was 4.51 × 10−3 hr.−1 cm.−2. Solubilities and dissolution rates were markedly lower in potassium chloride solutions. „Salting‐out”︁ coefficients were calculated, for the effect of potassium chloride on triamcinolone acetonide solubility, using the empirical Setschenow equation.
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