Abstract
Polylactic acid (PLA) is a polymer with an increased potential to be used in different medical applications, including tissue engineering and drug-carries. The use of PLA in medical applications implies the evaluation of the human organism's response to the polymer inserting and to its degradation products. Consequently, within this study, we have investigated the solubility and ADMET profiles of the short oligomers (having the molecular weight lower than 3000 Da) resulting in degradation products of PLA. There is a linear decrease of the molar solubility of investigated oligomers with molecular weight. The results that are obtained also reveal that short oligomers of PLA have promising pharmacological profiles and limited toxicological effects on humans. These oligomers are predicted as potential inhibitors of the organic anion transporting peptides OATP1B1 and OATP1B3, they present minor probability to affect the androgen and glucocorticoid receptors, have a weak potential of hepatotoxicity, and may produce eye injuries. These outcomes may be used to guide or to supplement in vitro and/or in vivo toxicity tests such as to enhance the biodegradation properties of the biopolymer.
Highlights
For a few decades, biopolymers are extensively in use as food additives, cosmetics, medical materials, water treatment chemicals, packaging, etc
Three methods are included in SwissADME to predict aqueous solubility: the Estimate SOLubility (ESOL) model [15], a method adapted from Ali and co-workers [16], and a method based on a system of 16 fragmental contributions modulated by the squared root of molecular weight implemented under FILTER-IT software, version 1.0.2
The obtained logS values are plotted against the molecular weight (Figures 2) and log P (Figures 3) and they were fitted with appropriate curves such as to obtain the highest values of the coefficients of determination (R squared)
Summary
Biopolymers are extensively in use as food additives, cosmetics, medical materials, water treatment chemicals, packaging, etc. Because of their intrinsic properties, especially non-cytotoxicity, biocompatibility and biodegradation, biopolymers are a class of materials that provides a wide range of applications in medicine [1]. They are considered outstanding candidates to be used for the preparation of many medical and body implants and as controlled drug delivery systems.
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