Abstract
The solubilities of mestanolone, methandienone, nandrolone and testosterone have been determined in the n-alkanes between C 7 and C 16 and in n-alkanols between C 5 and C 12. The mole fraction solubilities in the alkanes increased rectilinearly with the carbon number of the solvent, indicating a progressively decreasing increment in free energy of mixing for each additional methylene group. The solubilities in the alkanols of all the steroids except nandrolone, followed a parabolic relationship with carbon number and with solubility parameter of the solvent, and approximately fitted regular solution theory predictions. Divergences between observed and predicted solubilities were explained in terms of an interaction between solute and solvent which invalidated the geometric mean assumption. The suggestion was supported by thermodynamic measurements. Nandrolone showed decreasing solubility with increasing solvent carbon number. Its behaviour fitted the theory suggested for the other steroids and was confirmed by the thermodynamic data.
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