Abstract
The solubilities of 6-aminopenicillanic acid and phenoxyacetic acid were determined at 25 °C in aqueous solutions of several hydrotropes by the weight disappearance method at different hydrotrope concentrations. Commercially available aqueous hydrotrope solutions employed were 50 mass % sodium butyl monoglycol sulfate, 40 mass % sodium cumenesulfonate, 40 mass % sodium xylenesulfonate, and 40 mass % potassium−sodium xylenesulfonate, all the hydrotrope concentration mass percentages being expressed on a mass/mass basis. At high concentrations, above the threshold hydrotrope concentration, hydrotropes enhance the solubilities of these components differently. The ternary solid−liquid phase equilibrium diagram for the 6-aminopenicillanic acid−phenoxyacetic acid−water system with sodium butyl monoglycol sulfate as a hydrotrope was constructed. Solubilities of 6-aminopenicillanic acid were also determined in the reaction product mixture with or without the 30 mass % sodium butyl monoglycol sulfate hydrotropic m...
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