Abstract
The use of a multi-well system allowed us to measure the solubility of two anhydrous forms of olanzapine in pure solvents with different polarities in a temperature range of 20 to 60° Celsius (°C) with a small quantity of material. After that, we carried out cooling crystallization experiments in a stagnant medium with a small volume of 0.8 mL and a small quantity of material. We found that the solubility increased with the solvent polarity in the order: methanol > ethanol > acetonitrile > ethyl acetate > tetrahydrofuran > toluene. We demonstrated the effect of the solvents and the cooling rates on the crystal habit, crystal phase, and crystal size distribution.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
