Abstract
PATHOGENICITY of viruses is commonly related to their ability to multiply within the host's cells. Although, in certain conditions, the inoculation of large doses of uninfectious virus can produce a fatal disease1, the toxicity of viral components as such for laboratory animals has never been demonstrated. We have shown that although frog virus 3 (FV 3) is unable to multiply in mice, it produces an acute degenerative hepatitis leading to the death of the animals in less than 24 h (refs 2, 3). We report here that solubilised viral proteins also produce this hepatotoxic effect.
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