Abstract
Solitary neurofibroma is a benign nerve sheath neoplasm composed of Schwann cells, perineural cells, fibroblasts, mast cells, collagen, and blood vessels. Microscopically, the neurofibromas are further subclassified according to their growth patterns as classic, collagenous, cellular, myxoid, and pigmented. Oral cavity involvement in solitary neurofibroma in patients without neurofibromatosis is uncommon. The treatment is surgical excision. A 61-year-old woman complained of a mass, of 30 years' evolution, on the lower lip. Clinical examination showed a nodular lesion measuring 3 cm in diameter on the lower lip. Microscopic examination showed a proliferation of spindle cells with slender, often wavy nuclei embedded in a predominant collagenous stroma admixed with myxoid areas. Masson's trichrome staining highlighted a predominant collagenous stroma, and immunohistochemistry was positive for vimentin, S100, CD10, and CD34. Ki-67 labeling index was less than 5%. The diagnosis was localized neurofibroma with predominant collagenous stroma.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
