Abstract
To investigate the clinicopathological characteristics and possible causes of solitary necrotic nodule of the liver (SNN), two cases of SNN of the liver were studied with clinicopathological data, immunohistochemistry, and histochemistry staining. The patients had no specific symptoms, with negative results for the serum tumor markers. CT and ultrasound all showed low-density lesion. Morphologically, there was isolate, single necrosis tubercle of the liver. It was composed of a central necrotic core and a peripheral fibrotic capsule with inflammatory cells, including histiocytes, plasma cells, lymphocytes, and so forth. The staining result of PAS, acid-fast, and iron was all negative, and AG + VG staining showed that the outline of reticular fibers and collagen was intact. Vimtin was positive for necrotic tissue and surrounding fibrous tissue. CD34 and CD68 was both positive for case 1. CK was negative in case 2 but positive for a few residual cells in case 1. SNN of the liver is a rare nonmalignant disease with a good prognosis. Hemangioma and fatty liver might be ones of the causes of SNN.
Highlights
Solitary necrotic nodule (SNN) of liver is a rare benign disease which was first described by the Shepherd and Lee in 1983 [1] and few SNN cases has been reported in the literatures
SNN reported in the literature mostly was under the capsule, a small number in the liver parenchyma, and most of patients were located in the right lobe and the minority in the left
(b) Figure 3: The two patients both had the typical image of SNN (HE × 40). (a) Case 1; (b) Case 2
Summary
Solitary Necrotic Nodule of the Liver: A Report of Two Cases and Review of the Literature. To investigate the clinicopathological characteristics and possible causes of solitary necrotic nodule of the liver (SNN), two cases of SNN of the liver were studied with clinicopathological data, immunohistochemistry, and histochemistry staining. There was isolate, single necrosis tubercle of the liver. It was composed of a central necrotic core and a peripheral fibrotic capsule with inflammatory cells, including histiocytes, plasma cells, lymphocytes, and so forth. The staining result of PAS, acid-fast, and iron was all negative, and AG + VG staining showed that the outline of reticular fibers and collagen was intact. CK was negative in case 2 but positive for a few residual cells in case 1. Hemangioma and fatty liver might be ones of the causes of SNN
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