Abstract
Neurofibroma is a benign tumor derived from the peripheral nerve. Most of these can be multifocal as a component of neurofibromatosis or present as a solitary tumor. Although the solitary neurofibroma is not an uncommon lesion, its intraosseous occurrence is rare, and less than 50 cases have been reported.
 We report a rare case of central neurofibroma, arising in the mandibular bone of 57-year-old edentulous female patient on the left side. Hemi mandibulectomy was performed and reconstructed with a reconstruction plate without any bone graft. Microscopic evaluation showed neoplastic tissue with haphazardly arranged and interlacing fascicular patterns composed of point-ended spindle-shaped tumoral cells. Immunohistochemical examination of the tumor showed positive staining for S-100 protein antibodies.
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