Abstract
An efficient catalytic system for the C–H olefination of arenes with different allylic substrates is reported. The catalytic system is based on Pd(OAc)2 and a readily accessible bidentate S,O-ligand. The methodology shows high activity with a wide range of arenes, including bulky and, electron-rich and -poor arenes. The applicability of this catalyst is demonstrated in the late-stage functionalization of the complex molecule O-methylestrone.
Highlights
Kananat Naksomboon a, Yolanda Álvarez-Casao a, Michiel Uiterweerd a, Nick Westerveld a, Beatriz Maciá b, M
The catalytic system is based on Pd(OAc)[2] and a readily accessible bidentate S,O-ligand
We recently reported a new type of bidentate S,O-ligand, namely 2-i-propyl-2-(phenylthio) acetic acid (L1), that enables the non-directed Pd-catalyzed C–H olefination[5] of arenes with activated olefins.[6]
Summary
Kananat Naksomboon a, Yolanda Álvarez-Casao a, Michiel Uiterweerd a, Nick Westerveld a, Beatriz Maciá b, M. An efficient catalytic system for the C–H olefination of arenes with different allylic substrates is reported. We report the S,O-ligand promoted palladium(II)-catalyzed C–H olefination of arenes with allylic substrates.
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