Solid-phase synthesis of α-sulfonylamino amide derivatives based on Ugi-type condensation reaction using sulfonamides as amine input

Abstract

A method for solid-phase synthesis of α-sulfonylamino amides has been developed, which relies on a new Ugi-type 4-component condensation reaction involving arylsulfonamides as an amine input followed by removal of the acid moiety under the basic conditions. Either polymer-bound sulfonamides or carboxylic acids can be used in this reaction to afford structurally diverse products with good purity and in moderate to excellent yield.