Abstract
The solid-phase synthesis of di-N-acetyl-β-chitobiosyl allosamizoline 2 was reported. After the 6-O-benzyl allosamizoline 16, NHCbz trichloroacetimidate donors 7, and 14 were synthesized; solid-phase synthesis was performed using the Wang resin as support. The target di-N-acetyl-β-chitobiosyl allosamizoline 2 was obtained by iterative glycosylation reactions, catalytic hydrogenation, acetylation, and deacetylation, respectively. Keywords: Allosamidin analogue, di-N-acetyl-β-chitobiosyl allosamizoline, glycosylation reactions, solid-phase synthesis, trichloroacetimidate donors, wang resin, antifungal agents, Acetylation, Regioselective, diisopropylcarbodiimide
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