Abstract
A sensitive, reproducible, and rapid radioimmunoassay was developed to determine clastin peptide content of human serum in nanogram amounts. Significant differences have been determined between normal volunteers, both smokers and nonsmokers, and patients wth chronic obstructive pulmonary disease. The average concentration of clastin peptides in 9 normal nonsmokers was 19.88 ± 10.46 μg/ml serum, indistinguishable from that in 7 normal smokers which was 17.64 ± 8.54 μg/ml. Average concentration of clastin peptides in 17 patients with lung disease was 53.38 ± 22.46 μg/ml, significantly different ( P < 0.001) from the healthy control group. The method outlined shows excellent reproducibility on multiple determinations and allows analysis of as many as 100 samples in 6–8 h.
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