Abstract
Biomedical analyses of chemical agents and their metabolites are important in the development of new drugs, in therapeutic drug monitoring, and in forensic toxicology. In these analyses, sample preparation is essential for the isolation of desired components from complex biological matrices and greatly influences their reliable and accurate determination. Solid-phase microextraction (SPME) is an effective sample preparation technique that has enabled miniaturization, automation, and high-throughput performance. This article focuses on current developments and future trends in novel SPME techniques, including fiber SPME, in-tube SPME and related techniques for drug analysis, as well as their biomedical applications.
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